MACDONALD SE, NEWBURN‐COOK CV, ALLEN M and REUTTER L.Nursing Inquiry2013;20: 30–41 Embracing the population health framework in nursing researchIndividuals’ health outcomes are influenced not only by their knowledge and behavior, but also by complex social, political and economic forces. Attention to these multi‐level factors is necessary to accurately and comprehensively understand and intervene to improve human health. The population health framework is a valuable conceptual framework to guide nurse researchers in identifying and targeting the broad range of determinants of (...) health. However, attention to the intermediate processes linking multi‐level factors and use of appropriate multi‐level theory and research methodology is critical to utilizing the framework effectively. Nurse researchers are well equipped to undertake such investigations but need to consider a number of political, societal, professional and organizational barriers to do so. By fully embracing the population health framework, nurse researchers have the opportunity to explore the multi‐level influences on health and to develop, implement and evaluate interventions that target immediate needs, more distal factors and the intermediate processes that connect them. (shrink)

Warrior cultures throughout history have developed unique codes that restrict their behavior and set them apart from the rest of society. But what possible reason could a warrior have for accepting such restraints? Why should those whose profession can force them into hellish kill-or-be-killed conditions care about such lofty concepts as honor, courage, nobility, duty, and sacrifice? And why should it matter so much to the warriors themselves that they be something more than mere murderers? The Code of the Warrior (...) tackles these timely issues and takes the reader on a tour of warrior cultures and their values, from the ancient Greeks and Romans to the 'barbaric' Vikings and Celts, from legendary chivalric knights to Native American tribesmen, from Chinese warrior monks pursuing enlightenment to Japanese samurai practicing death. Drawing these rich traditions up to the present, the author quests for a code for the warriors of today, as they do battle in asymmetric conflicts against unconventional forces and the scourge of global terrorism. (shrink)

How is a disease contracted, and how does it progress through the body? Answers to these questions are fundamental to understanding both basic biology and medicine. Advances in the biomedical sciences continue to provide more tools to address these fundamental questions and to uncover questions that have not been thought of before. Despite these major advances, we are still facing conceptual and technical challenges when learning about the etiology of disease, especially for genetic diseases. In this review, we illustrate this (...) point by discussing the causal links between molecular mechanisms and systems-level phenotypes in molecular diseases. We begin with an examination of sickle cell anemia, and how mechanisms of the disease have been comprehended over the last century. While sickle cell anemia involves a mutation in a single protein in a single cell type, other diseases involve mutations in networks with many protein interactions and in diverse cell types. We introduce the challenges that result from these differences and illustrate the current obstacles by discussing the RASopathies, a recently discovered class of developmental syndromes that result from mutations in signaling networks. Methods to study mutant genotypes that lead to mutant phenotypes are discussed, particularly the use of model organisms and mutant proteins to study protein interactions that may be important for development of disease. These studies will point toward the future of diagnosing and treating genetic disease. (shrink)

Drawing on philosophy, history, moral psychology, and ethics, this revised and expanded edition of French’s The Code of the Warrior examines historical and contemporary warrior cultures and their values, arguing that today’s warriors need a code, as their ancestors did, to prevent them from crossing the thin but critical line that separates warriors from murderers in the battle against global terrorism.

In medieval Europe, knights were permitted to settle disputes through trial by combat. This was a practice whereby members of the noble class who were accused of a crime could defend themselves not...

This paper addresses the concern that despite centuries of analysis of jus ad helium and jus in hello, the pernicious view persists that war is a separate and amoral sphere: "C'est la guerre!" In fact, there are and must be rules for armed conflicts, and foul offenses such as rape and murder are not excused by war. What individuals do beyond the bounds of jus in hello reveals and affects their character as much as actions taken in more peaceful contexts. (...) Traditional martial virtues such as loyalty and discipline, if they are not undermined by mixed signals from leadership or corrupted by an unethical command climate, can be used to bolster the warrior's commitment to exercising restraint in wartime. These virtues remain accessible to the warrior even when dehumanization of the enemy dampens the mind's capacity for empathy and produces moral callousness. (shrink)

Symbolic arithmetic is fundamental to science, technology and economics, but its acquisition by children typically requires years of effort, instruction and drill1,2. When adults perform mental arithmetic, they activate nonsymbolic, approximate number representations3,4, and their performance suffers if this nonsymbolic system is impaired5. Nonsymbolic number representations also allow adults, children, and even infants to add or subtract pairs of dot arrays and to compare the resulting sum or difference to a third array, provided that only approximate accuracy is required6–10. Here (...) we report that young children, who have mastered verbal counting and are on the threshold of arithmetic instruction, can build on their nonsymbolic number system to perform symbolic addition and subtraction11–15. Children across a broad socio-economic spectrum solved symbolic problems involving approximate addition or subtraction of large numbers, both in a laboratory test and in a school setting. Aspects of symbolic arithmetic therefore lie within the reach of children who have learned no algorithms for manipulating numerical symbols. Our findings help to delimit the sources of children’s difficulties learning symbolic arithmetic, and they suggest ways to enhance children’s engagement with formal mathematics. We presented children with approximate symbolic arithmetic problems in a format that parallels previous tests of non-symbolic arithmetic in preschool children8,9. In the first experiment, five- to six-year-old children were given problems such as ‘‘If you had twenty-four stickers and I gave you twenty-seven more, would you have more or less than thirty-five stickers?’’. Children performed well above chance (65.0%, t1952.77, P 5 0.012) without resorting to guessing or comparison strategies that could serve as alternatives to arithmetic. Children who have been taught no symbolic arithmetic therefore have some ability to perform symbolic addition problems. The children’s performance nevertheless fell short of performance on non-symbolic arithmetic tasks using equivalent addition problems with numbers presented as arrays of dots and with the addition operation conveyed by successive motions of the dots into a box (71.3% correct, F1,345 4.26, P 5 0.047)8.. (shrink)

Substance P and related tachykinin peptides probably act as neurotransmitters or modulators of neurotransmission, and regulate biological processes as diverse as salivary secretion and transmission of pain signals. Substance P peptide sequences are expressed in three distinct mRNAs that are generated from one gene by differential RNA splicing. In addition to substance P, as many as three other tachykinin peptides can be generated from the polyprotein precursors by differential posttranslational processing. Three tachykinin receptor subtypes have been extensively characterized which differentially (...) interact with the naturally occurring tachykinin peptides. Therefore, the generation of diversity of tachykinin peptides results from differential precursor RNA splicing and differential posttranslational processing. The specificity of peptide responses is the result of selective receptor subtype expression. (shrink)

It’s a commonplace that Federal Reserve chairman Ben Bernanke draws his policies from Milton Friedman and Anna Schwartz’s A Monetary History of the United States. With that in mind, this article establishes five points. First, contrary to conventional wisdom, Friedman and Schwartz merely insinuate their claim the Fed caused the Depression in MH. Second, their criticisms of Fed policy during the Depression, which turn on its refusal to adopt open market purchases, repudiate Friedman’s famed libertarianism and market fundamentalism. Third, Friedman (...) and Schwartz don’t refute the practical objections of bankers who opposed OMPs in the 1930s. Consequently, Bernanke’s policies for addressing the financial crisis risk doing precisely what Friedman’s targets warned against—encouraging financial speculation without addressing problems of unemployment. Fourth, Friedman and Schwartz’s prescriptions entail a neoliberal, not a libertarian, state, one governed by technocrats and answerable to financial markets. Finally, what accounts for and unifies Friedman’s contradictions is the beneficiary—finance. (shrink)

Epilepsy surgery is the most effective therapeutic approach for children with drug resistant epilepsy. Recent advances in neurosurgery, such as the Laser Interstitial Thermal Therapy, improved the safety and non-invasiveness of this method. Electric and magnetic source imaging plays critical role in the delineation of the epileptogenic focus during the presurgical evaluation of children with DRE. Yet, they are currently underutilized even in tertiary epilepsy centers. Here, we present a case of an adolescent who suffered from DRE for 16 years (...) and underwent surgery at Cook Children's Medical Center. The patient was previously evaluated in a level 4 epilepsy center and treated with multiple antiseizure medications for several years. Presurgical evaluation at CCMC included long-term video electroencephalography, magnetoencephalography with simultaneous conventional EEG and high-density EEG in two consecutive sessions, MRI, and fluorodeoxyglucose - positron emission tomography. Video long-term EEG captured nine focal-onset clinical seizures with a maximal evolution over the right frontal/frontal midline areas. MRI was initially interpreted as non-lesional. FDG-PET revealed a small region of hypometabolism at the anterior right superior temporal gyrus. ESI and MSI performed with dipole clustering showed a tight cluster of dipoles in the right anterior insula. The patient underwent intracranial EEG which indicated the right anterior insular as seizure onset zone. Eventually LITT rendered the patient seizure free. Retrospective analysis of ESI and MSI clustered dipoles found a mean distance of dipoles from the ablated volume ranging from 10 to 25 mm. Our findings highlight the importance of recent technological advances in the presurgical evaluation and surgical treatment of children with DRE, and the underutilization of epilepsy surgery in children with DRE. (shrink)

This study investigates potential differences in attitudes towards corporate social responsibility between Saudis and Muslims from other predominately Islamic countries. We propose that Saudi Arabia’s unique rentier-state welfare and higher education systems account for these distinctions. In evaluating our propositions, we replicate Brammer et al. :229–243, 2007) survey on attitudes towards CSR using a sample of Saudi undergraduate and graduate business students and compare the results against data from subjects in other majority Muslim countries. In addition, this work examines possible (...) differences within the Saudi sample with respect to sex and academic level. Our results indicate that our Saudi subjects maintain higher expectations for corporations’ social responsibility within their supply chain than the Brammer et al.’s sample. In contrast, Muslims in the Brammer et al.’s sample hold higher expectations for corporations in supporting societal development and poverty alleviation in comparison to the Saudi sample. We also find within the Saudi sample that females and subjects at higher academic levels are more inclined to hold corporations responsible for social issues related to CSR than males and subjects in lower academic levels. We examine these findings, explore their implications, and propose areas for future research. (shrink)

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

In this article, we explore the implications of opposing domains theory for developing ethical leaders. Opposing domains theory highlights a neurological tension between analytic reasoning and socioemotional reasoning. Specifically, when we engage in analytic reasoning, we suppress our ability to engage in socioemotional reasoning and vice versa. In this article, we bring together the domains of neuroscience, psychology, and ethics, to inform our theorizing around ethical leadership. We propose that a key issue for ethical leadership is achieving a healthy balance (...) between analytic reasoning and socioemotional reasoning. We argue that organizational culture often encourages too heavy a reliance on nonemotional forms of reasoning to arrive at moral judgments. As a result, leaders run the risk of suppressing their ability to pay attention to the human side of moral dilemmas and, in doing so, dehumanize colleagues, particularly subordinates, and clients. (shrink)

Researchers are required to seek consent from Indigenous communities prior to conducting research but there is inadequate information about how Indigenous people understand and become fully engaged with this consent process. Few studies evaluate the preference or understanding of the consent process for research with Indigenous populations. Lack of informed consent can impact on research findings. The Picture Talk Project was initiated with senior Aboriginal leaders of the Fitzroy Valley community situated in the far north of Western Australia. Aboriginal people (...) were interviewed about their understanding and experiences of research and consent processes. Transcripts were analysed using NVivo10 software with an integrated method of inductive and deductive coding and based in grounded theory. Local Aboriginal interpreters validated coding. Major themes were defined and supporting quotes sourced. Interviews with Aboriginal leaders were facilitated by a local Aboriginal Community Navigator who could interpret if necessary and provide cultural guidance. Participants were from all four major local language groups of the Fitzroy Valley; aged 31 years and above; and half were male. Themes emerging from these discussions included Research—finding knowledge; Being respectful of Aboriginal people, Working on country, and Being flexible with time; Working together with good communication; Reciprocity—two-way learning; and Reaching consent. The project revealed how much more there is to be learned about how research with remote Aboriginal communities should be conducted such that it is both culturally respectful and, importantly, meaningful for participants. We identify important elements in community consultation about research and seeking consent. (shrink)

Current discussions of business ethics usually only consider deontological and utilitarian approaches. What is missing is a discussion of traditional teleology, often referred to as virtue ethics. While deontology and teleology are useful, they both suffer insufficiencies. Traditional teleology, while deontological in many respects, does not object to utilitarian style calculations as long as they are contained within a moral framework that is not utilitarian in its origin. It contains the best of both approaches and can be used to focus (...) on the individual''s role within an organization. More work is needed in exposing students and faculty to traditional teleology and its place in business ethic''s discussions. (shrink)

Disciplinary boundaries become increasingly unclear when grappling with “wicked problems,” which present a complex set of policy, cultural, technological, and scientific dimensions. “T-shaped” professionals, i.e. individuals with a depth and breadth of expertise, are being called upon to play a critical role in complex problem-solving. This paper unpacks the notion of the “T-shaped expert” and seeks to situate it within the broader academic literature on expertise, integration, and developmental learning. A component of this project includes an exploratory study, which is (...) aimed at evaluating the emergent attributes of T-shaped expertise in two different educational programs completed between January and May in 2015. The two programs build disciplinary knowledge in science, technology engineering, and mathematics fields at the core, while expanding the students’ awareness and comprehension of other expertise. The courses introduced science and engineering students to case study topics focusing around complex human-technological-ecological systems in a nanotechnology and society course; and the governance of genetically modified organisms in a science, technology, and society course. We analyze pre- and post-test data from this pilot project before presenting findings that pertain to student learning, as well as variants in the methodology and reflect on the utility of the selected methodology for evaluating expertise as it evolves over time. The paper closes with a discussion of a theory of acquisition with implications for delineating early attributes and characteristics of T-shaped expertise. (shrink)

This new annotated translation of Chapter Six of Hegel's _Phenomenology of Spirit_, the joint product of a group of scholars that included H. S. Harris, George di Giovanni, John W. Burbidge, and Kenneth Schmitz, represents an advance in accuracy and fluency on previous translations into English of this core chapter of the Phenomenology. Its notes and commentary offer both novice and scholar more guidance to this text than is available in any other translation, and it is thus well suited for (...) use in survey courses. (shrink)

Examined as an isolated situation, and through the lens of a rare and feared disease, Mr. Duncan's case seems ripe for second-guessing the physicians and nurses who cared for him. But viewed from the perspective of what we know about errors and team communication, his case is all too common. Nearly 440,000 patient deaths in the U.S. each year may be attributable to medical errors. Breakdowns in communication among health care teams contribute in the majority of these errors. The culture (...) of health care does not seem to foster functional, effective communication between and among professionals. Why? And more importantly, why do we not do something about it? (shrink)

Many of you may be familiar with what is today called the “Gaia hypothesis.” It consists in the thesis that the earth is a super-organism that exhibits specific properties of life: It regulates its own temperature, “excretes” waste, combats poisonous “infections,” and the like. In a word, it maintains homoeostasis. The hypothesis has supposedly been established by using a scientific method: the proposal of a hypothesis putatively based on observation and the reasonable explanation of the data. It was offered ostensibly (...) as the only viable explanation for a vast host of natural phenomena, of which the actual processes and mechanics are not truly understood. I will note just a few of these. (shrink)

This paper addresses the concern that despite centuries of analysis of jus ad helium and jus in hello, the pernicious view persists that war is a separate and amoral sphere: "C'est la guerre!" In fact, there are and must be rules for armed conflicts, and foul offenses such as rape and murder are not excused by war. What individuals do beyond the bounds of jus in hello reveals and affects their character as much as actions taken in more peaceful contexts. (...) Traditional martial virtues such as loyalty and discipline, if they are not undermined by mixed signals from leadership or corrupted by an unethical command climate, can be used to bolster the warrior's commitment to exercising restraint in wartime. These virtues remain accessible to the warrior even when dehumanization of the enemy dampens the mind's capacity for empathy and produces moral callousness. (shrink)

The 91st annual meeting of the American Philosophical Association, Central Division, took place in Chicago this spring at the Palmer House. To the delight of many, Hegel topics were present and Hegelians were in good attendance. There were two fine discussions of Hegel’s works and ideas.

In the section called “Observation of Nature” in the Phenomenology of Spirit, Hegel considers and criticizes a particular form of methodology which seeks final purposes by analogy. Through this methodology what is essential for thought is the recognition and demarcation of differentiae, which are imputed to natural objects as qualities by which things maintain their distinct and separate character - what Hegel calls their “being-for-self.” By these differentiae, then, the objects are categorized into types, or “natural kinds,” which, in turn, (...) are interpreted by natural philosophers according to a projected teleological system. Hegel’s critique is not aimed primarily at the categorization of objects, but at the method of interpretation used to characterize these categories as purposeful. In particular, Hegel is not criticizing the use of analogy as discussed in the biological writings of Aristotle, but the use of analogy by the transcendental idealists, especially Kant, who employs this method in the Critique of Judgment. (shrink)

This paper considers Hegel’s treatment of the dispute between modern philosophy and faith in his Phenomenology of Spirit. The paper shows that Hegel is concerned with this dispute as part of his systematic program to advance the true philosophical concept of self and world, but, by so doing, he supports ahumanistic reconciliation between Christianity and the secular values of the Enlightenment. The paper contains extensive discussions of Hegel’s views on the French philosophes, and it shows how he used their writings (...) in his criticism of the popular notions within denominational religion. It also shows why Hegel did not fully support the philosophes’ assumptions, but, instead, he was willing to accept Christian notions of the incarnation and redemption. (shrink)

The paper deals with the H. S. Harris's work on Hegel. It considers how he presented the Phenomenology of Spirit in his graduate seminars and what the first drafts, which were offered in class, were like in contrast to the published version of Hegel's Ladder.

An important role for all health care professionals is to be an advocate for their patients, and there is no question that many patients need advocacy to reach their health care goals. The role of advocate takes many forms, but one is to speak up when one is concerned for the safety or well‐being of a patient. A nurse is often the member of a health care team most likely to notice changes that might signal problems or poor responses to (...) treatment. The duty of the nurse is to speak up in a timely and urgent manner when the nurse believes—or fears—that the patient's safety may be at risk. Yet the role of nurses as advocates for their patients has assumed near‐mythic status. Rather than seeing advocate as one among many equally important and interrelated professional roles, the nurse, when asked, “Who are you?” is likely to give the heartfelt and passionate answer, “The patient's advocate!” This essay examines and critically analyzes the advocacy role adopted by the nursing profession and outlines the challenges it has created to nursing's contributions to collaborative practice, ethics, and policy in health care. (shrink)

ObjectiveOverweight and obesity [body mass index ≥ 25 kg/m2] are associated with poorer prognosis among women with breast cancer, and weight gain is common during treatment. Symptoms of depression and anxiety are also highly prevalent in women with breast cancer and may be exacerbated by post-diagnosis weight gain. Altered brain function may underlie psychological distress. Thus, this secondary analysis examined the relationship between BMI, psychological health, and resting state functional connectivity among women with breast cancer.MethodsThe sample included 34 post-menopausal women (...) newly diagnosed with Stage 0-IIa breast cancer who were enrolled in a 6-month randomized controlled trial of aerobic exercise vs. usual care. At baseline prior to randomization, whole-brain analyses were conducted to evaluate the relationship between BMI and seed-to-voxel rsFC of the hippocampus and amygdala. Connectivity values from significant clusters were then extracted and examined as predictors of self-reported depression and anxiety.ResultsMean BMI was in the obese range. For both seeds examined, higher BMI was associated with lower rsFC with regions of prefrontal cortex, including ventrolateral PFC, dorsolateral PFC, and superior frontal gyrus. Hippocampal connectivity with the vlPFC was negatively correlated with self-reported anxiety.ConclusionHigher BMI was associated with lower hippocampal and amygdala connectivity to regions of PFC implicated in cognitive control and emotion regulation. BMI-related differences in hippocampal and amygdala connectivity following a recent breast cancer diagnosis may relate to future worsening of psychological functioning during treatment and remission. Additional longitudinal research exploring this hypothesis is warranted. (shrink)

The paper examines the relationship between beauty and goodness in Hegel's Lectures on Aesthetics. The paper explains that Hegel rejects certain art works as "wicked" not simply because they lack unity and intelligibility but because they undermine claims to Providence. Hegel's understanding of the connection between art, morality, and religion is further related to Kenneth Schmitz's papers that explore the same relationship.

Hegel’s Phenomenology of Spirit was the introduction and first part of the Jena System III; it was to introduce the other parts of his project. Most commentators on Hegel’s Phenomenology, however, do not consider how the Phenomenology relates to the other parts, and some discount Hegel’s understanding and commitment to the natural philosophy of his day. This paper attempts to make the connection between the Phenomenology and the Natural Philosophy of 1805-6 explicit; to show where and how the connections are (...) made; to identify how Hegel uses the natural sciences of his day in creating his system. By showing these relations we should recognize that his concept of Spirit is born within his natural philosophy. It is part of his cosmology. (shrink)

The paper deals with Schelling's lectures on the Philosophy of Mythology. It examines his idea of how the idea of God is rooted in social history and culture of a people. The Greek and Jewish experience is contrasted. There is consideration of why Schelling rejects Hume's interpretation of religion. Schelling's own reliance on "positive" expression of religion is explored and criticized.

This volume contains eleven essays dealing with the question of how to face the current challenges of globalization. The essays included in this volume were originally presented at the Renvall Institute for Area and Cultural Studies, University of Helsinki, Finland, on the occasion of the Sixth World Congress of the International Society for Universal Dialogue (ISUD) Presents Keynote addresses or prize-winning papers from the Congress Central theme explores the need to rethink our concepts of nature, culture, and freedom in an (...) age of increased globalization Topics examined range from global justice, international law, and human rights to ecoterrorism, cultural relativism, and the challenges of autonomy. (shrink)

Most commentators who consider Hegel's treatment of the female principle (Weiblichkeit) in the Phenomenology of Spirit only believe that it refers to "True Spirit" and is limited to a brief discussion of Sophocles's character Antigone. This is not actually true. The paper deals with both with the broader question of who represents the female principle and also goes into detail on the first appearance of Antigone in chapter five and on her final appearance in chapter seven, Reason. The female principle (...) returns in Religion as an aspect of Absolute Being. The female goddesses, especially the mother goddess and the Erinyes, embody this principle. Antigone reappears as offering prophetic wisdom for their mission, which is Divine Law and justice. (shrink)

Many of you may be familiar with what is today called the “Gaia hypothesis.” It consists in the thesis that the earth is a super-organism that exhibits specific properties of life: It regulates its own temperature, “excretes” waste, combats poisonous “infections,” and the like. In a word, it maintains homoeostasis. The hypothesis has supposedly been established by using a scientific method: the proposal of a hypothesis putatively based on observation and the reasonable explanation of the data. It was offered ostensibly (...) as the only viable explanation for a vast host of natural phenomena, of which the actual processes and mechanics are not truly understood. I will note just a few of these. (shrink)

This paper considers Hegel’s treatment of the dispute between modern philosophy and faith in his Phenomenology of Spirit. The paper shows that Hegel is concerned with this dispute as part of his systematic program to advance the true philosophical concept of self and world, but, by so doing, he supports ahumanistic reconciliation between Christianity and the secular values of the Enlightenment. The paper contains extensive discussions of Hegel’s views on the French philosophes, and it shows how he used their writings (...) in his criticism of the popular notions within denominational religion. It also shows why Hegel did not fully support the philosophes’ assumptions, but, instead, he was willing to accept Christian notions of the incarnation and redemption. (shrink)